When it comes to non-surgical facial rejuvenation, Radiesse and Sculptra are two of the most advanced options available. Both are biostimulant fillers, meaning they don’t just add volume—they stimulate collagen production for longer-lasting, natural results. But which one is right for you?

Understanding the differences in longevity, composition, and results can help you make an informed decision. Whether you’re looking for instant volume or gradual improvement, knowing what to expect from these treatments will ensure you choose the best fit for your aesthetic goals.

What Are Biostimulant Fillers?

Unlike traditional dermal fillers, which primarily use hyaluronic acid to provide instant plumping, biostimulant fillers stimulate the body’s natural collagen production. This means results develop over time and can last significantly longer than standard fillers.

Both Radiesse and Sculptra fall into this category, but they work in very different ways.

• Radiesse provides immediate volume with long-term collagen stimulation.
• Sculptra offers gradual volume restoration over several months by encouraging deep collagen renewal.

Choosing between these two depends on your treatment goals, how soon you want to see results, and how long you want them to last.

Radiesse: Instant Volume With Long-Lasting Benefits

How Radiesse Works

Radiesse is made from Calcium Hydroxylapatite (CaHA) microspheres suspended in a water-based gel. It provides immediate volume upon injection while also stimulating collagen production over time.

This makes it an excellent option for deep wrinkles, facial contouring, and even hand rejuvenation.

Key Benefits of Radiesse

• Immediate plumping effect for deeper lines and wrinkles.
• Stimulates collagen for long-term skin firming.
• Ideal for cheek enhancement, jawline contouring, and nasolabial folds.
• Long-lasting results of 12–18 months.
• Also used for hand rejuvenation to restore lost volume.

How Long Does Radiesse Last?

Results typically last 12 to 18 months, depending on:

• Metabolism rate (faster metabolisms break down fillers more quickly).
• Treatment area (facial areas may metabolize it differently than hands).
• Lifestyle factors such as sun exposure, smoking, and skincare routine.

Touch-up treatments can help extend Radiesse’s effects, ensuring continued collagen stimulation and prolonged results.

Sculptra: Gradual, Long-Term Volume Restoration

How Sculptra Works

Sculptra is composed of poly-L-lactic acid (PLLA), a biodegradable substance that stimulates deep collagen renewal. Unlike Radiesse, Sculptra does not provide instant volume. Instead, results develop gradually over several monthsas collagen production increases.

Key Benefits of Sculptra

• Stimulates collagen production for natural, long-lasting results.
• Ideal for full-face rejuvenation, including cheeks, temples, and jawline.
• Results develop gradually, avoiding an overfilled or artificial look.
• Can last over two years, making it one of the longest-lasting fillers.
• Provides a softer, more natural enhancement compared to traditional fillers.

How Long Does Sculptra Last?

Sculptra is known for its impressive longevity. Results can last two years or more, with some clinical studies showing benefits lasting up to 25 months.

However, the treatment process is more gradual than Radiesse:

• Most patients require 3–4 sessions over a few months to achieve optimal results.
• Full effects become visible 3–6 months after the first treatment.
• Maintenance treatments every 18–24 months help sustain collagen production.

This makes Sculptra an excellent choice for those looking for long-term improvement rather than immediate correction.

Radiesse vs. Sculptra: Key Differences

Feature	Radiesse	Sculptra
Main Ingredient	Calcium Hydroxylapatite (CaHA)	Poly-L-lactic acid (PLLA)
How It Works	Provides immediate volume & stimulates collagen	Gradually increases collagen for long-term volume
Best For	Deep wrinkles, jawline, cheek contouring, hands	Full-face volume loss, hollow areas, temples
How Long Results Last	12–18 months	2+ years
Time to See Results	Immediate	Gradual (3–6 months)
Number of Treatments Needed	1 session	3–4 sessions over a few months

Which Biostimulant Filler Is Right for You?

Choose Radiesse If:

• You want instant volume along with collagen stimulation.
• You need deep wrinkle correction or facial contouring.
• You’re looking for a faster treatment with long-lasting effects (12–18 months).
• You want hand rejuvenation in addition to facial enhancement.

Choose Sculptra If:

• You prefer a gradual, natural-looking transformation.
• You need full-face rejuvenation, including cheeks, temples, and chin.
• You’re looking for the longest-lasting filler (2+ years).
• You don’t mind waiting a few months to see progressive improvement.

If you’re unsure, a consultation with a skilled aesthetic provider can help determine the best option for your needs.

Cost Comparison: Radiesse vs. Sculptra

While prices vary based on location and provider, here’s a general cost breakdown:

• Radiesse: $650–$800 per syringe
• Sculptra: $750–$1,000 per vial

Sculptra may seem more expensive upfront, but since results last twice as long, it often provides better long-term value.

Radiesse, on the other hand, requires fewer treatments to achieve visible results, making it ideal for those who want a cost-effective solution with immediate impact.

Possible Side Effects and Safety Considerations

Both Radiesse and Sculptra are FDA-approved and safe when administered by an experienced injector. However, potential side effects include:

• Mild swelling and redness at the injection site.
• Bruising, which usually subsides within a few days.
• Tenderness or itching, especially in sensitive areas.
• Small lumps or nodules, which are rare but more common with Sculptra.

Choosing a qualified, board-certified injector ensures optimal results and minimizes risks.

The Bottom Line: Which Lasts Longer?

Sculptra’s ability to last over two years comes from its unique mechanism of action. Instead of simply filling in wrinkles and adding volume, it works by stimulating your body’s natural collagen production, creating a more gradual and long-lasting improvement in skin structure. However, this process requires patience and commitment. Unlike Radiesse, where results are visible immediately, Sculptra takes several months to fully develop. Patients typically need three to four sessions spaced four to six weeks apart, as each treatment builds upon the previous one to restore lost facial volume and improve skin quality over time.

Radiesse, on the other hand, is ideal for those who want instant results with a collagen-boosting bonus. Its calcium hydroxylapatite (CaHA) microspheres provide immediate structural support while also stimulating collagen production for continued improvement after the initial treatment. While Radiesse doesn’t last as long as Sculptra, its 12–18 month duration makes it an excellent choice for patients looking for a quicker, more noticeable enhancement. This makes Radiesse particularly popular for jawline contouring, cheek augmentation, and deep wrinkle correction, where patients want instant lift and definition.

Ultimately, the choice between Sculptra and Radiesse depends on your aesthetic goals and timeline. If you prefer a slow, natural transformation with long-lasting effects, Sculptra is the better option. However, if you want immediate results with a moderate collagen-stimulating effect, Radiesse may be the right fit. Many patients also choose a combination approach, using Radiesse for immediate enhancement and Sculptra for long-term collagen renewal, ensuring both instant gratification and lasting rejuvenation. Consulting with a skilled aesthetic provider can help determine the best strategy for your specific needs.

Ready to Enhance Your Look? Book a Free Consultation in Yorkville

Whether you’re considering Radiesse for instant lift or Sculptra for long-term collagen regeneration, choosing the right filler requires expert guidance.

At VBeauty Medical Spa in Yorkville, our expert injectors specialize in customized aesthetic treatments designed to enhance your natural beauty.

Book your free consultation today to discuss your options and find the perfect treatment for your goals. Click here to schedule your appointment!